Cocaine sensitization models an anhedonia-like condition in rats
نویسندگان
چکیده
منابع مشابه
Role of dopamine D3 receptors in controlling the expression of cocaine sensitization in rats.
It is established that dopamine (DA) is an important brain mediator of the behavioral (i.e. sensitizing) effects of cocaine in rodents. Among DA receptors, recent findings point to engagement of DA D3 receptors in cocaine addictive actions. In the present study, we attempted to determine the role of DA D3 receptors in the expression phase of sensitization to cocaine in rats, using the selective...
متن کاملShort Communication Role of Dopamine D3 Receptors in Controlling the Expression of Cocaine Sensitization in Rats
It is established that dopamine (DA) is an important brain mediator of the behavioral (i.e. sensitizing) effects of cocaine in rodents. Among DA receptors, recent findings point to engagement of DA D receptors in cocaine addictive actions. In the present study, we attempted to determine the role of DA D receptors in the expression phase of sensitization to cocaine in rats, using the selective l...
متن کاملBehavioral effects of endogenous or exogenous estradiol and progesterone on cocaine sensitization in female rats
Cocaine sensitization is a marker for some facets of addiction, is greater in female rats, and may be influenced by their sex hormones. We compared the modulatory effects of endogenous or exogenous estradiol and progesterone on cocaine-induced behavioral sensitization in 106 female rats. Ovariectomized female rats received progesterone (0.5 mg/mL), estradiol (0.05 mg/mL), progesterone plus estr...
متن کاملCocaine Sensitization Increases Kyphosis and Modulates Neural Activity in Adult Nulliparous Rats
Although data from both animals and humans suggests that adult cocaine use can have long term effects on behavior, it is unknown if prior cocaine use affects future maternal behavior in nulliparous females. In the current study, cocaine or saline was administered to adult female rats for 10 days, the animals were withdrawn from cocaine for 7 days, and the females were then exposed to donor pups...
متن کاملFemale gonadal hormones differentially modulate cocaine-induced behavioral sensitization in Fischer, Lewis, and Sprague-Dawley rats.
Evidence suggests the existence of genetic differences in cocaine sensitization in male rats. The present study was undertaken to investigate cocaine sensitization in female rats of genetically distinct inbred (Fischer 344 and Lewis) and outbred (Sprague-Dawley) strains. All female rats were bilaterally ovariectomized and randomly assigned to one of four experimental groups: 1) estradiol benzoa...
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ژورنال
عنوان ژورنال: International Journal of Neuropsychopharmacology
سال: 2011
ISSN: 1469-5111,1461-1457
DOI: 10.1017/s1461145710000532